{"type":"research","record":{"id":5401,"source_id":"pubmed","external_id":"42545731","title":"Oxidative stress, aging, metabolism, SIRT1, and the gut microbiota: the neurocardiac basis of cognitive loss.","authors":"Kenneth Maiese","journal":"Medical gas research","published_on":"2026-08-03","doi":"10.4103/mgr.MEDGASRES-D-26-00073","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42545731/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Medical gas research, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:23.625+00:00","first_seen_at":"2026-09-16T01:17:03.743662+00:00","last_seen_at":"2026-09-16T06:17:23.625+00:00","status":"published","metadata":{"pmid":"42545731","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Sirtuin 1","Oxidative Stress","Gastrointestinal Microbiome","Aging","Animals","Cognitive Dysfunction"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Cardiovascular disease and cognitive loss have a neurocardiac basis. Poor vascular perfusion can impair cognitive funct…","controlled_terms":["Humans","Sirtuin 1","Oxidative Stress","Gastrointestinal Microbiome","Aging","Animals","Cognitive Dysfunction","APOE","Alzheimer’s disease","GLP-1","cardiac disease","cell senescence","dementia","diabetes mellitus","gut microbiota","mechanistic target of rapamycin (mTOR)","mitochondria","multiple sclerosis","oxidative stress","programmed cell death","silent mating type information regulation 2 homolog 1 (SIRT1)"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: rapamycin.","quality_checked_at":"2026-09-16T06:17:23.755824+00:00","duplicate_cluster_key":"id:10 4103 mgr medgasres-d-26-00073","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: rapamycin.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5401","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}