{"type":"research","record":{"id":5403,"source_id":"pubmed","external_id":"42551770","title":"Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle.","authors":"Jonas Boritz Kristiansen, Jacob Andresen, Jesper Emil Jakobsgaard, Kristian Vissing","journal":"Experimental gerontology","published_on":"2026-08-04","doi":"10.1016/j.exger.2026.113265","publication_type":"Journal Article","evidence_level":"preclinical","source_url":"https://pubmed.ncbi.nlm.nih.gov/42551770/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Preclinical research published by Experimental gerontology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:24.954+00:00","first_seen_at":"2026-09-16T01:17:03.743662+00:00","last_seen_at":"2026-09-16T06:17:24.954+00:00","status":"published","metadata":{"pmid":"42551770","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Female","Mechanistic Target of Rapamycin Complex 1","Aging","Muscle, Skeletal","Smad2 Protein","Phosphorylation","Mice","Signal Transduction","Mice, Inbred C57BL","Mechanotransduction, Cellular","Multiprotein Complexes","TOR Serine-Threonine Kinases","Stress, Mechanical"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Aging is associated with impaired skeletal muscle mass and function, often attributed to reduced sensitivity to anaboli… Using an ex vivo model, extensor digitorum longus (EDL) muscles from adult (16 weeks) and old (24 months) fem… Passive stretch significantly increased phosphorylation of mTORC1-related proteins (mTOR, p70S6K, rpS6, and 4E-BP1) in… Our findings reveal that mechanosensitive anabolic signaling is differentially affected by aging. While the intrinsic c…","controlled_terms":["Animals","Female","Mechanistic Target of Rapamycin Complex 1","Aging","Muscle, Skeletal","Smad2 Protein","Phosphorylation","Mice","Signal Transduction","Mice, Inbred C57BL","Mechanotransduction, Cellular","Multiprotein Complexes","TOR Serine-Threonine Kinases","Stress, Mechanical","Anabolic signaling","Ex vivo","JNK","Mechanotransduction","Passive stretch","SMAD","Skeletal muscle","mTORC1"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: rapamycin.","quality_checked_at":"2026-09-16T06:17:25.066664+00:00","duplicate_cluster_key":"id:10 1016 j exger 2026 113265","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: rapamycin.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5403","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}