{"type":"research","record":{"id":5431,"source_id":"pubmed","external_id":"42737424","title":"Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy.","authors":"Marta Grycan, Rafał Zyśk, Gabriela Grycan, Grzegorz Jakiel, Alicja Dudek, Grażyna Gromadzka","journal":"International journal of molecular sciences","published_on":"2026-08-22","doi":"10.3390/ijms27177521","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42737424/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by International journal of molecular sciences, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:23.625+00:00","first_seen_at":"2026-09-16T01:17:03.743662+00:00","last_seen_at":"2026-09-16T06:17:23.625+00:00","status":"published","metadata":{"pmid":"42737424","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Aging","Animals","Metabolic Networks and Pathways","Biomarkers","Protective Agents"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Aging is the strongest risk factor for chronic diseases such as cardiovascular diseases, cancer, diabetes, and neurodeg…","controlled_terms":["Humans","Aging","Animals","Metabolic Networks and Pathways","Biomarkers","Protective Agents","GLP-1 receptor agonists","NAD+ precursors","SGLT2 inhibitors","geroprotection","geroprotectors","longevity","menopausal hormone therapy","metformin","rapamycin","senolytics","statins","taurine"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: rapamycin.","quality_checked_at":"2026-09-16T06:17:23.755824+00:00","duplicate_cluster_key":"id:10 3390 ijms27177521","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Source terminology contains: metformin.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Metformin","slug":"metformin"}},{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: rapamycin.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5431","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}