{"type":"research","record":{"id":5437,"source_id":"pubmed","external_id":"42572918","title":"A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health.","authors":"Igor Goryanin, Bob Damms, Irina Goryanin","journal":"CPT: pharmacometrics & systems pharmacology","published_on":"2026-08-01","doi":"10.1002/psp4.70322","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42572918/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by CPT: pharmacometrics & systems pharmacology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:03.743662+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42572918","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Semaglutide","Aging","Weight Loss","Metformin","Sirolimus","Drug Therapy, Combination","Bayes Theorem","Sodium-Glucose Transporter 2 Inhibitors","Hypoglycemic Agents","Glucagon-Like Peptide-1 Receptor Agonists","Models, Biological","Glycated Hemoglobin","Network Pharmacology","Glucagon-Like Peptides"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Aging is a systems-level process linking metabolic dysfunction, inflammation, impaired repair, frailty, and multimorbid…","controlled_terms":["Humans","Semaglutide","Aging","Weight Loss","Metformin","Sirolimus","Drug Therapy, Combination","Bayes Theorem","Sodium-Glucose Transporter 2 Inhibitors","Hypoglycemic Agents","Glucagon-Like Peptide-1 Receptor Agonists","Models, Biological","Glycated Hemoglobin","Network Pharmacology","Glucagon-Like Peptides","Bayesian meta‐analysis","GLP‐1 receptor agonists","SBML","aging","combination therapy","identifiability","model‐informed drug development","quantitative systems pharmacology","rapamycin"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1002 psp4 70322","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Source terminology contains: metformin.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Metformin","slug":"metformin"}},{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: rapamycin, sirolimus.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5437","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}