{"type":"research","record":{"id":5455,"source_id":"pubmed","external_id":"42413386","title":"A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis.","authors":"Qi Han, Fenglin Jiang, Hao Deng, Alimire Alifu, Jiaqi Li, Zhuo Chen, Linlin Deng, Xiaoxiao Cai, Yu Chen, Yunfeng Lin","journal":"Biomaterials","published_on":"2026-07-06","doi":"10.1016/j.biomaterials.2026.124425","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42413386/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Biomaterials, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42413386","source":"NCBI PubMed E-utilities","mesh_terms":["Metformin","Animals","Chondrocytes","Osteoarthritis","Nanoparticles","DNA","Rats, Sprague-Dawley","DNA Nanostructures","Male","Rats","Drug Delivery Systems","Humans","Cellular Senescence"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Overcoming short intra-articular retention and poor chondrocyte uptake of drugs remains a major challenge for osteoarth…","controlled_terms":["Metformin","Animals","Chondrocytes","Osteoarthritis","Nanoparticles","DNA","Rats, Sprague-Dawley","DNA Nanostructures","Male","Rats","Drug Delivery Systems","Humans","Cellular Senescence","Cellular senescence","Chondrocyte targeting","Mitochondrial dysfunction","Tetrahedral DNA"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1016 j biomaterials 2026 124425","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Source terminology contains: metformin.","Source terminology supplies longevity context: senescence."],"matched_fields":["title","controlled terminology","controlled context"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5455","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}