{"type":"research","record":{"id":5459,"source_id":"pubmed","external_id":"42548921","title":"Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.","authors":"Yijun Wang, Yi Qin, Tianhao Wang, Wenhao Zhang, Kai Chen, Dechun Geng, Zhanjun Yan, Yaozeng Xu, Shujun Lv","journal":"Regenerative therapy","published_on":"2026-07-25","doi":"10.1016/j.reth.2026.101164","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42548921/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Regenerative therapy, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42548921","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"The senescence and abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) are important caus… The senescence of BMSCs were induced by hydrogen peroxide (H 2 O 2 ) to assess the therapeutic effect of PUN. Intracell… PUN reversed the senescence of BMSCs and promoted the osteogenic differentiation in a dose-dependent manner. Mechanisti… PUN alleviates senile osteoporosis by inhibiting the senescence of BMSCs via NRF2/HO-1 pathway, representing a candidat…","controlled_terms":["Cellular senescence","Mesenchymal stem cells","NRF2","Punicalagin","Senile osteoporosis"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1016 j reth 2026 101164","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}},{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Source terminology contains: stem cell.","Title supplies longevity context: senescence."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5459","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}