{"type":"research","record":{"id":5461,"source_id":"pubmed","external_id":"42464532","title":"Recombinant human collagen XVII protects epidermal stem cells from blue light-induced photoaging by downregulating the Notch pathway.","authors":"Xudong Wang, Qiang Li, Xin Yang, Yu Bai, Shijia Sui, Ge Ge, Haitao Li, Rongya Yang","journal":"Annals of medicine","published_on":"2026-07-16","doi":"10.1080/07853890.2026.2694876","publication_type":"Journal Article; Research Support, Non-U.S. Gov't","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42464532/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Annals of medicine, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42464532","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Collagen Type XVII","Skin Aging","Blue Light","Humans","Rats","Rats, Sprague-Dawley","Stem Cells","Non-Fibrillar Collagens","Recombinant Proteins","Receptors, Notch","Signal Transduction","Down-Regulation","Cellular Senescence","Male","Epidermal Cells","Epidermis"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Epidermal stem cell (ESC) degeneration is closely associated with skin aging and functional deterioration. Type XVII co… Blue light-induced photoaging models were established using in vitro ESCs and in vivo Sprague-Dawley rats. Transcriptom… In photoaging ESCs, rhCol17 enhanced ESC viability and migratory capacity, decreased senescence cells, while suppressin… This study demonstrates that rhCol17 counteracts blue light-induced ESC dysfunction and epidermal photoaging, suggestin…","controlled_terms":["Animals","Collagen Type XVII","Skin Aging","Blue Light","Humans","Rats","Rats, Sprague-Dawley","Stem Cells","Non-Fibrillar Collagens","Recombinant Proteins","Receptors, Notch","Signal Transduction","Down-Regulation","Cellular Senescence","Male","Epidermal Cells","Epidermis","Photoaging","Recombinant human collagen","blue light","epidermal stem cells","stemness"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1080 07853890 2026 2694876","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}},{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Source terminology contains: stem cell.","Title supplies longevity context: aging."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5461","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}