{"type":"research","record":{"id":5462,"source_id":"pubmed","external_id":"42501452","title":"Discovery of a quinoline-based senomorphic agent for the treatment of chronic kidney disease.","authors":"Youyou Chen, Sicong Qiao, Xin Chen, Linfen Li, Jiale Wu, Centao Shi, Jian Li, Yuan Guo, Yunyuan Huang, Wenwen Liu","journal":"European journal of medicinal chemistry","published_on":"2026-07-17","doi":"10.1016/j.ejmech.2026.119164","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42501452/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by European journal of medicinal chemistry, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:34.651+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:34.651+00:00","status":"published","metadata":{"pmid":"42501452","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Quinolines","Caenorhabditis elegans","Mice","Renal Insufficiency, Chronic","Humans","Cellular Senescence","Molecular Structure","Structure-Activity Relationship","Drug Discovery","Dose-Response Relationship, Drug","Senotherapeutics"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Senescence is a risk factor for chronic diseases, making anti-aging interventions a promising strategy for geriatric co…","controlled_terms":["Animals","Quinolines","Caenorhabditis elegans","Mice","Renal Insufficiency, Chronic","Humans","Cellular Senescence","Molecular Structure","Structure-Activity Relationship","Drug Discovery","Dose-Response Relationship, Drug","Senotherapeutics","Anti-aging","C. elegans","Cellular senescence","Chronic kidney disease","Senotherapy"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: senomorphic.","quality_checked_at":"2026-09-16T06:17:34.765074+00:00","duplicate_cluster_key":"id:10 1016 j ejmech 2026 119164","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: senomorphic.","Source terminology contains: cellular senescence.","Abstract supplies longevity context: aging, senescence."],"matched_fields":["title","controlled terminology","abstract context"],"relevance_score":100,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5462","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}