{"type":"research","record":{"id":5466,"source_id":"pubmed","external_id":"42612745","title":"PRMT5 lactylation mediates SIRT6-dependent DNA damage and senescence in benzene-induced hematotoxicity.","authors":"Rongli Sun, Kai Xu, Xiaoqin Li, Jiawei Huang, Daqin Wang, Yuepu Pu, Juan Zhang","journal":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","published_on":"2026-08-18","doi":"10.1016/j.fct.2026.116343","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42612745/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Food and chemical toxicology : an international journal published for the British Industrial Biological Research Associ…, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42612745","source":"NCBI PubMed E-utilities","mesh_terms":["Sirtuins","Benzene","DNA Damage","Cellular Senescence","Humans","DNA Breaks, Double-Stranded"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Benzene exposure induces hematotoxicity, partially through disrupted DNA damage repair. SIRT6 is a key regulator of bot…","controlled_terms":["Sirtuins","Benzene","DNA Damage","Cellular Senescence","Humans","DNA Breaks, Double-Stranded","DNA damage","Hematotoxicity","PRMT5 lactylation","SIRT6","Senescence"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: cellular senescence.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1016 j fct 2026 116343","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5466","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}