{"type":"research","record":{"id":5480,"source_id":"pubmed","external_id":"42376011","title":"Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress.","authors":"Qianyi Ren, Xingyu Zhu, Yujiao Zhai, Guangyu Rong, Xujiao Zhou, Jia Lv, Jiaxu Hong, Yiyun Cheng","journal":"Bioactive materials","published_on":"2026-06-17","doi":"10.1016/j.bioactmat.2026.06.014","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42376011/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Bioactive materials, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T01:17:20.627+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T01:17:20.627+00:00","status":"published","metadata":{"pmid":"42376011","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Dry eye disease (DED) is a prevalent, age-related ocular disorder that severely impairs vision and quality of life. Age…","controlled_terms":["Amphiphilic polymer","Cellular senescence","Dry eye disease","Intracellular Protein delivery","Oxidative stress"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: senolytic, cellular senescence.","quality_checked_at":"2026-09-16T01:17:20.773489+00:00","duplicate_cluster_key":"id:10 1016 j bioactmat 2026 06 014","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: senolytic, cellular senescence.","Source terminology contains: cellular senescence.","Title supplies longevity context: senescence, age-related."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5480","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}