{"type":"research","record":{"id":5488,"source_id":"pubmed","external_id":"42492237","title":"Luteolin is associated with alleviation of cigarette smoke-induced cellular senescence and inflammation in mice involving the CREB/c-Fos/NQO1 pathway.","authors":"Jieying Tao, Kelan Zhao, Yeling Ni, Ziyu Yu, Lu Wang","journal":"International immunopharmacology","published_on":"2026-07-23","doi":"10.1016/j.intimp.2026.117177","publication_type":"Journal Article","evidence_level":"preclinical","source_url":"https://pubmed.ncbi.nlm.nih.gov/42492237/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Preclinical research published by International immunopharmacology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:34.651+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:34.651+00:00","status":"published","metadata":{"pmid":"42492237","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","NAD(P)H Dehydrogenase (Quinone)","Luteolin","Cellular Senescence","Cyclic AMP Response Element-Binding Protein","Mice","Proto-Oncogene Proteins c-fos","Signal Transduction","Cell Line","Smoke","Epithelial Cells","Mice, Inbred C57BL","Lung","Anti-Inflammatory Agents","Male","Cigarette Smoking","Inflammation","Cytokines","Pulmonary Disease, Chronic Obstructive"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Cigarette smoke (CS) exposure is a major risk factor for chronic obstructive pulmonary disease (COPD) and is closely as…","controlled_terms":["Animals","NAD(P)H Dehydrogenase (Quinone)","Luteolin","Cellular Senescence","Cyclic AMP Response Element-Binding Protein","Mice","Proto-Oncogene Proteins c-fos","Signal Transduction","Cell Line","Smoke","Epithelial Cells","Mice, Inbred C57BL","Lung","Anti-Inflammatory Agents","Male","Cigarette Smoking","Inflammation","Cytokines","Pulmonary Disease, Chronic Obstructive","CREB","Cigarette smoke (CS)","NQO1","Senescence"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: cellular senescence.","quality_checked_at":"2026-09-16T06:17:34.765074+00:00","duplicate_cluster_key":"id:10 1016 j intimp 2026 117177","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: cellular senescence.","Source terminology contains: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5488","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}