{"type":"research","record":{"id":5490,"source_id":"pubmed","external_id":"42632331","title":"Low expression of PDGFR-β impairs the blood-brain barrier and accelerates cellular aging in the hippocampal region.","authors":"Haichao Chen, Le Zhang, Xiaoling Zhu, Cheng Gu, Fulin Gao","journal":"Biochemical and biophysical research communications","published_on":"2026-08-18","doi":"10.1016/j.bbrc.2026.154456","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42632331/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Biochemical and biophysical research communications, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42632331","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Blood-Brain Barrier","Receptor, Platelet-Derived Growth Factor beta","Hippocampus","Pericytes","Cellular Senescence","Mice","Mice, Knockout","Neurogenesis","Mice, Inbred C57BL"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Platelet-Derived Growth Factor Receptor Beta (PDGFR-β), a key marker of cerebrovascular pericytes, plays a crucia… Using PDGFR-β heterozygous knockout (PDGFR-β+/-) mice, we systematically examined pericyte coverage, BBB in… PDGFR-β ± mice exhibited significant pericyte loss, reduced tight junction proteins, impaired… Our findings establish that PDGFR-β haploinsufficiency drives pericyte loss and BBB breakdown, leading to hippoca…","controlled_terms":["Animals","Blood-Brain Barrier","Receptor, Platelet-Derived Growth Factor beta","Hippocampus","Pericytes","Cellular Senescence","Mice","Mice, Knockout","Neurogenesis","Mice, Inbred C57BL","Aging","Blood-brain barrier","Platelet-derived growth factor receptor β"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: cellular senescence.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1016 j bbrc 2026 154456","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: aging."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5490","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}