{"type":"research","record":{"id":5492,"source_id":"pubmed","external_id":"42624351","title":"Aging as cross-hallmark obstruction amplification: A sheaf-theoretic model of repair closure, senescence, inflammation, and regenerative failure.","authors":"J J Segura","journal":"Bio Systems","published_on":"2026-08-20","doi":"10.1016/j.biosystems.2026.105924","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42624351/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Bio Systems, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42624351","source":"NCBI PubMed E-utilities","mesh_terms":["Aging","Regeneration","Humans","Models, Biological","Inflammation","Animals","Cellular Senescence"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"The twelve hallmarks of aging describe heterogeneous molecular, cellular, tissue, and systemic changes but do not by th…","controlled_terms":["Aging","Regeneration","Humans","Models, Biological","Inflammation","Animals","Cellular Senescence","Autopoiesis","Cellular senescence","Cohomology","Hallmarks of aging","Persistence","Repair closure","Sheaf theory","Stem-cell exhaustion"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: cellular senescence.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1016 j biosystems 2026 105924","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: aging, senescence."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5492","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}