{"type":"research","record":{"id":5495,"source_id":"pubmed","external_id":"42595025","title":"Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions.","authors":"Ruohui Tang, Jin Yin, Shidan Li, Shaochuan Wang, Jun Fei, Zhaowen Zhou","journal":"Experimental gerontology","published_on":"2026-08-13","doi":"10.1016/j.exger.2026.113276","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42595025/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Experimental gerontology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:34.651+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:34.651+00:00","status":"published","metadata":{"pmid":"42595025","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Mitochondria","Cellular Senescence","Chondrocytes","Animals","Intervertebral Disc Degeneration","Mitophagy","Reactive Oxygen Species"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Intervertebral disc degeneration (IVDD) is a leading global cause of chronic pain and functional impairment. The senesc…","controlled_terms":["Humans","Mitochondria","Cellular Senescence","Chondrocytes","Animals","Intervertebral Disc Degeneration","Mitophagy","Reactive Oxygen Species","Endplate cartilage","Mitochondrial dynamics","Oxidative stress","Senescence"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: cellular senescence.","quality_checked_at":"2026-09-16T06:17:34.765074+00:00","duplicate_cluster_key":"id:10 1016 j exger 2026 113276","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5495","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}