{"type":"research","record":{"id":5496,"source_id":"pubmed","external_id":"42594754","title":"6-Shogaol attenuates liver fibrosis by driving hepatic stellate cell senescence through the cGAS-STING-NF-κB axis.","authors":"Yuzhe Liu, Shang Wang, Wang Peng, Qinyi Xu, Chunlai Feng, Dazhi Ke, Jianwei Wang","journal":"Phytomedicine : international journal of phytotherapy and phytopharmacology","published_on":"2026-08-06","doi":"10.1016/j.phymed.2026.158693","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42594754/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Phytomedicine : international journal of phytotherapy and phytopharmacology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:34.651+00:00","first_seen_at":"2026-09-16T01:17:05.283419+00:00","last_seen_at":"2026-09-16T06:17:34.651+00:00","status":"published","metadata":{"pmid":"42594754","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Hepatic Stellate Cells","NF-kappa B","cGAS-STING Signaling Pathway","Liver Cirrhosis","Membrane Proteins","Cellular Senescence","Mice","Catechols","Humans","Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","STING Protein","Male","Mice, Inbred C57BL","Nucleotidyltransferases","Zingiber officinale","Signal Transduction","Cell Line","Carbon Tetrachloride"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Liver fibrosis represents a frequent pathological outcome of chronic hepatic insults. As a bioactive constituent of gin… To assess the anti-fibrotic effects of 6-shogaol and elucidate the molecular mechanisms, we focused on its impact on th… A CCl₄-induced mouse model and LX-2 cells were employed to evaluate the antifibrotic efficacy of 6-shogaol and e… Treatment with 6-shogaol alleviated hepatic injury, inflammation, and fibrogenesis in mice, while suppressing HSC activ… Treatment with 6-shogaol attenuates liver fibrosis by driving HSC senescence through the cGAS-STING-NF-κB axis. T…","controlled_terms":["Animals","Hepatic Stellate Cells","NF-kappa B","cGAS-STING Signaling Pathway","Liver Cirrhosis","Membrane Proteins","Cellular Senescence","Mice","Catechols","Humans","Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","STING Protein","Male","Mice, Inbred C57BL","Nucleotidyltransferases","Zingiber officinale","Signal Transduction","Cell Line","Carbon Tetrachloride","6-Shogaol","Hepatic stellate cell","Liver fibrosis","Senescence","cGAS-STING-NF-κB"],"relevance_confidence":65,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: cellular senescence.","quality_checked_at":"2026-09-16T06:17:34.765074+00:00","duplicate_cluster_key":"id:10 1016 j phymed 2026 158693","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Source terminology contains: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["controlled terminology","title context"],"relevance_score":65,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5496","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}