{"type":"research","record":{"id":5506,"source_id":"pubmed","external_id":"42409289","title":"Aging of mesenchymal stem cells in bone aging: Mechanisms, impact, and therapeutic perspectives.","authors":"Zimo Zhou, Heran Wang, Zhuoru Jin, Boya Wen, Tong Wu, Tiantong Zhu, Da Liu","journal":"Ageing research reviews","published_on":"2026-07-06","doi":"10.1016/j.arr.2026.103240","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42409289/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Ageing research reviews, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:33.208+00:00","first_seen_at":"2026-09-16T01:17:07.052612+00:00","last_seen_at":"2026-09-16T06:17:33.208+00:00","status":"published","metadata":{"pmid":"42409289","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Mesenchymal Stem Cells","Aging","Cellular Senescence","Animals","Epigenesis, Genetic","Bone and Bones","Senescence-Associated Secretory Phenotype","Cell Differentiation"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Aging of the skeleton is a hallmark of organismal decline and underlies prevalent age-related disorders such as osteopo…","controlled_terms":["Humans","Mesenchymal Stem Cells","Aging","Cellular Senescence","Animals","Epigenesis, Genetic","Bone and Bones","Senescence-Associated Secretory Phenotype","Cell Differentiation","Bone aging","Epigenetic regulation","MSC senescence","Metabolic reprogramming","SASP","Senolytics"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-16T06:17:33.31458+00:00","duplicate_cluster_key":"id:10 1016 j arr 2026 103240","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Source terminology contains: stem cell.","Title supplies longevity context: aging."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5506","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}