{"type":"research","record":{"id":5552,"source_id":"pubmed","external_id":"42551713","title":"Lung function after randomization to metformin, lifestyle intervention or placebo in the Diabetes Prevention Program Outcomes Study (DPPOS).","authors":"Carrie L Pistenmaa, Lindsay Doherty, Emilia A Hermann, Angela L Brown, Dana Dabelea, Fernando Holguin, Karol Watson, William C Knowler, Marinella Temprosa, R Graham Barr, DPP Research Group","journal":"Respiratory medicine","published_on":"2026-08-04","doi":"10.1016/j.rmed.2026.109077","publication_type":"Journal Article; Randomized Controlled Trial","evidence_level":"randomized-human","source_url":"https://pubmed.ncbi.nlm.nih.gov/42551713/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Randomized human study published by Respiratory medicine, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:24.954+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:24.954+00:00","status":"published","metadata":{"pmid":"42551713","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Metformin","Female","Spirometry","Hypoglycemic Agents","Male","Aged","Diabetes Mellitus, Type 2","Middle Aged","Life Style","Forced Expiratory Volume","Vital Capacity","Respiratory Function Tests","Treatment Outcome"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Metformin and physical activity have been suggested as beneficial for chronic lung disease; however, there are no prior… The Diabetes Prevention Program (DPP) was a 3-year trial that randomized 3234 individuals at risk for diabetes to metfo… The 1888 participants with spirometry were a mean (±SD) age of 68.2 ± 9.3 years, 70% female and… In this long-term follow-up after a randomized trial, we found no significant associations between randomization to met…","controlled_terms":["Humans","Metformin","Female","Spirometry","Hypoglycemic Agents","Male","Aged","Diabetes Mellitus, Type 2","Middle Aged","Life Style","Forced Expiratory Volume","Vital Capacity","Respiratory Function Tests","Treatment Outcome"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:25.066664+00:00","duplicate_cluster_key":"id:10 1016 j rmed 2026 109077","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Study type is explicitly identified as Journal Article; Randomized Controlled Trial."],"matched_fields":["title","abstract","controlled terminology","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5552","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}