{"type":"research","record":{"id":556,"source_id":"europe-pmc","external_id":"42723264","title":"EXPRESS: Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial.","authors":"Aware C, Neher CM, Woods C, Khegai O, Dwivedi AK, Govindarajan M, Ivanich K, Kurt M, Beversdorf D, Cheng J, Bresette N, Cui T, Balchandani P, Gonzales MM, Ericsson AC, Altes T, Lin AL.","journal":null,"published_on":"2026-09-10","doi":"10.1177/0271678x261490342","publication_type":null,"evidence_level":"research-record","source_url":"https://europepmc.org/article/MED/42723264","is_open_access":false,"cited_by_count":0,"editorial_summary":"Research record, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-15T00:17:12.67+00:00","first_seen_at":"2026-09-14T02:54:55.535855+00:00","last_seen_at":"2026-09-15T00:17:12.67+00:00","status":"published","metadata":{"pmid":"42723264","pmcid":null,"source":"MED","has_references":false},"integrity_checked_at":"2026-09-15T00:18:38.043+00:00","abstract_text":null,"controlled_terms":[],"relevance_confidence":75,"source_quality_score":90,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 75% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"doi:10.1177/0271678x261490342","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Legacy record evaluated automatically against controlled title and longevity-context rules."],"matched_fields":["title"],"relevance_score":75,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"Europe PMC","homepage_url":"https://europepmc.org/"}},"canonical_url":"https://www.immortal.life/research/556","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}