{"type":"research","record":{"id":5560,"source_id":"pubmed","external_id":"42521161","title":"Chronological lifespan extension evaluation-driven comparative study of five Indian dietary spices for geroprotective action via phytochemical profiling, bioactivity screening and network pharmacology in Saccharomyces cerevisiae.","authors":"Aaysha Gupta, Sonam Chawla","journal":"Fitoterapia","published_on":"2026-07-28","doi":"10.1016/j.fitote.2026.107399","publication_type":"Journal Article; Comparative Study","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42521161/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Fitoterapia, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42521161","source":"NCBI PubMed E-utilities","mesh_terms":["Saccharomyces cerevisiae","Plant Extracts","Spices","Antioxidants","Network Pharmacology","Phytochemicals","India","Longevity","Oxidative Stress","Anti-Inflammatory Agents","Cuminum","Metformin"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Indian dietary spices are emerging to have nutraceutical potential; however, their role iFn modulating longevity remain… In the Phase 1, assessment of anti-oxidant potential, anti-inflammatory activity, and yeast cell proliferation action w… F. vulgare extract characterisation indicated presence of diverse phytocompounds (40 compounds) and high phenolic and f… FV's geroprotective effect, akin to metformin (positive control) is likely linked to its rich phytochemical makeup. This study highlights F. vulgare as a potential natural geroprotector in yeast, necessitating validation in higher mode…","controlled_terms":["Saccharomyces cerevisiae","Plant Extracts","Spices","Antioxidants","Network Pharmacology","Phytochemicals","India","Longevity","Oxidative Stress","Anti-Inflammatory Agents","Cuminum","Metformin","Anti-oxidant","Indian dietary spices extract","LC-MS/MS","Network pharmacology","Stress tolerance","Yeast chronological lifespan extension"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1016 j fitote 2026 107399","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Title supplies longevity context: lifespan."],"matched_fields":["abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5560","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}