{"type":"research","record":{"id":5568,"source_id":"pubmed","external_id":"42295772","title":"Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes.","authors":"Marcel E Salive, Ashley H Tjaden, Jesse R Ames, Jill P Crandall, Dana Dabelea, Helen P Hazuda, Brandy M Heckman-Stoddard, Peter J Huckfeldt, Shihchen Kuo, Elsa S Strotmeyer, Marinella Temprosa, Elizabeth M Venditti, DPP Research Group","journal":"JAMA","published_on":"2026-08-18","doi":"10.1001/jama.2026.8492","publication_type":"Journal Article; Multicenter Study; Observational Study; Randomized Controlled Trial","evidence_level":"randomized-human","source_url":"https://pubmed.ncbi.nlm.nih.gov/42295772/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Randomized human study published by JAMA, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42295772","source":"NCBI PubMed E-utilities","mesh_terms":["Aged","Female","Humans","Male","Middle Aged","Diabetes Mellitus, Type 2","Follow-Up Studies","Hypoglycemic Agents","Metformin","Multimorbidity","Prediabetic State","Chronic Disease","Healthy Lifestyle","Prevalence","Aged, 80 and over","Cost of Illness","Treatment Outcome"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Studying how to prevent or delay not just 1 disease but multiple chronic conditions is of great importance for public h… To examine the association of lifestyle or metformin compared with placebo on long-term multimorbidity in adults with p… Observational follow-up cohort study of a randomized clinical trial conducted at 27 sites in the United States from Jun… Participants in DPP were randomly assigned to intensive lifestyle intervention, metformin, or placebo. During DPPOS, me… The primary outcome was multimorbidity (presence of ≥2 of 15 prevalent conditions, defined in CMS' Chronic Condi… Of the 1173 participants (median age, 74 years [IQR, 70-80]; 795 [68%] were female), 997 (85%) experienced greater than… Among adults with prediabetes at baseline, lifestyle intervention, but not metformin, was associated with a lower burde… ClinicalTrials.gov Identifier: DPP, NCT00004992; DPPOS, NCT00038727.","controlled_terms":["Aged","Female","Humans","Male","Middle Aged","Diabetes Mellitus, Type 2","Follow-Up Studies","Hypoglycemic Agents","Metformin","Multimorbidity","Prediabetic State","Chronic Disease","Healthy Lifestyle","Prevalence","Aged, 80 and over","Cost of Illness","Treatment Outcome"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1001 jama 2026 8492","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Study type is explicitly identified as Journal Article; Multicenter Study; Observational Study; Randomized Controlled…."],"matched_fields":["title","abstract","controlled terminology","study type"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5568","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}