{"type":"research","record":{"id":5569,"source_id":"pubmed","external_id":"42593551","title":"Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers.","authors":"Jorge Arriagada, Matías Lantadilla, Pedro Lobos, Adolfo A Paz, Emilio A Herrera, Pablo Muñoz, Andrea Paula-Lima","journal":"Neurotoxicity research","published_on":"2026-08-13","doi":"10.1007/s12640-026-00819-w","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42593551/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Neurotoxicity research, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42593551","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","NF-E2-Related Factor 2","Amyloid beta-Peptides","Metformin","Kelch-Like ECH-Associated Protein 1","Hippocampus","Neurons","Lipid Peroxidation","Signal Transduction","Antioxidants","Cells, Cultured","Rats","Peptide Fragments","Oxidative Stress"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Oxidative stress is an early and important feature of Alzheimer's disease (AD) that contributes to synaptic dysfunction…","controlled_terms":["Animals","NF-E2-Related Factor 2","Amyloid beta-Peptides","Metformin","Kelch-Like ECH-Associated Protein 1","Hippocampus","Neurons","Lipid Peroxidation","Signal Transduction","Antioxidants","Cells, Cultured","Rats","Peptide Fragments","Oxidative Stress","Alzheimer's disease","Amyloid-β oligomers","Antioxidant defenses","Nrf2/KEAP1 pathway"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1007 s12640-026-00819-w","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Source terminology contains: metformin."],"matched_fields":["title","controlled terminology"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5569","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}