{"type":"research","record":{"id":5575,"source_id":"pubmed","external_id":"42587816","title":"Metformin Inhibits Cardiac Fibroblast Differentiation by Promoting Fatty Acid β-Oxidation: Implications for Age-Associated Cardiac Fibrosis.","authors":"Hridya Chempon, Sunita Kumari, Srinivasa Reddy Bonam, Srigiridhar Kotamraju","journal":"Cells","published_on":"2026-08-04","doi":"10.3390/cells15151408","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42587816/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Cells, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42587816","source":"NCBI PubMed E-utilities","mesh_terms":["Metformin","Animals","Fatty Acids","Cell Differentiation","Fibroblasts","Fibrosis","Oxidation-Reduction","Mice","Cellular Senescence","Myocardium","Aging","Mitochondria","Carnitine O-Palmitoyltransferase","Mice, Inbred C57BL","Transforming Growth Factor beta"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Cardiac fibrosis is a hallmark of pathological cardiac remodeling, characterized by fibroblast activation, excessive ex…","controlled_terms":["Metformin","Animals","Fatty Acids","Cell Differentiation","Fibroblasts","Fibrosis","Oxidation-Reduction","Mice","Cellular Senescence","Myocardium","Aging","Mitochondria","Carnitine O-Palmitoyltransferase","Mice, Inbred C57BL","Transforming Growth Factor beta","CPT1","FAO","cardiac fibrosis","metformin","senescence"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 3390 cells15151408","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Source terminology contains: metformin.","Source terminology supplies longevity context: aging, senescence."],"matched_fields":["title","controlled terminology","controlled context"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5575","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}