{"type":"research","record":{"id":5581,"source_id":"pubmed","external_id":"41942023","title":"Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression.","authors":"Abdullah I Aedh, Hayder M Al-Kuraishy, Mustafa M Shokr, Mubarak Alruwaili, Gaber El-Saber Batiha","journal":"Molecular and cellular endocrinology","published_on":"2026-04-04","doi":"10.1016/j.mce.2026.112802","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/41942023/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Molecular and cellular endocrinology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"41942023","source":"NCBI PubMed E-utilities","mesh_terms":["Metformin","Humans","Aging","Animals","AMP-Activated Protein Kinases","Signal Transduction","Hypoglycemic Agents","Senescence-Associated Secretory Phenotype","Enzyme Activation","Autophagy","Cellular Senescence","TOR Serine-Threonine Kinases"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Biological aging is the risk factor underlying most of the chronic diseases of late life, such as cardiovascular diseas…","controlled_terms":["Metformin","Humans","Aging","Animals","AMP-Activated Protein Kinases","Signal Transduction","Hypoglycemic Agents","Senescence-Associated Secretory Phenotype","Enzyme Activation","Autophagy","Cellular Senescence","TOR Serine-Threonine Kinases","AMP-activated protein kinase","Biological aging","Cellular senescence","Mechanistic target of rapamycin"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1016 j mce 2026 112802","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Source terminology contains: metformin.","Title supplies longevity context: aging."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5581","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}