{"type":"research","record":{"id":5583,"source_id":"pubmed","external_id":"42620010","title":"A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance.","authors":"Nicolas Musi, Chen-Pin Wang, Daniel MacCarthy, Zhaohong Feng, Jacob T Holmes, Masayoshi Suda, Tamar Pirtskhalava, Arianne Aslamy, Jonathan Wanagat, Robert Brooke, Tamar Tchkonia, James L Kirkland, Steve Horvath, Sara E Espinoza","journal":"medRxiv : the preprint server for health sciences","published_on":"2026-07-28","doi":"10.64898/2026.07.27.26359055","publication_type":"Journal Article; Preprint","evidence_level":"preprint","source_url":"https://pubmed.ncbi.nlm.nih.gov/42620010/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Preprint — not peer reviewed published by medRxiv : the preprint server for health sciences, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42620010","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Preclinical and human observational studies suggest that metformin may decrease age-related pathology, including frailt… Determine whether metformin reduces frailty progression and biological age in older adults with glucose intolerance, a… Randomized, double-blind, placebo-controlled trial of metformin in 145 non-frail or pre-frail older adults. Participant… Effect on frailty was primarily determined using generalized estimating equations by change in the Fried frailty phenot… Metformin led to a non-linear response in the Fried score rate of change, with an upward trajectory in year 1 (0.72&#xb… Metformin halts the progression of the deficit accumulation frailty index and reduces biological age, suggesting potent… ClinicalTrials.gov : NCT02570672 . Question: Does metformin slow progression of frailty and biological aging in older adults? Findings: In this randomized…","controlled_terms":[],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 64898 2026 07 27 26359055","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Title contains controlled term: metformin.","Abstract contains controlled term: metformin.","Title supplies longevity context: frailty, frail."],"matched_fields":["title","abstract","title context"],"relevance_score":100,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5583","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}