{"type":"research","record":{"id":5593,"source_id":"pubmed","external_id":"42229415","title":"Reductive death is averted by a conserved de novo lipogenic switch.","authors":"Fasih M Ahsan, Jen F Rotti, Armen I Yerevanian, Sinclair W Emans, Nicole L Stuhr, Jose A Aceves-Salvador, Wei Wang, Daniel J Baker, Dimitra Pouli, Owen S Skinner, Michael D Blower, Alexander A Soukas","journal":"Molecular cell","published_on":"2026-06-02","doi":"10.1016/j.molcel.2026.05.011","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42229415/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Molecular cell, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:22.206+00:00","first_seen_at":"2026-09-16T01:17:08.657654+00:00","last_seen_at":"2026-09-16T06:17:22.206+00:00","status":"published","metadata":{"pmid":"42229415","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Lipogenesis","Metformin","NADP","Caenorhabditis elegans","Biguanides","Longevity","Oxidation-Reduction","Caenorhabditis elegans Proteins","NAD","Fatty Acids","Glutathione","Phenformin","Hypoglycemic Agents"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Biguanides, including metformin, the world's most prescribed oral hypoglycemic, extend health span and lifespan in vert…","controlled_terms":["Animals","Lipogenesis","Metformin","NADP","Caenorhabditis elegans","Biguanides","Longevity","Oxidation-Reduction","Caenorhabditis elegans Proteins","NAD","Fatty Acids","Glutathione","Phenformin","Hypoglycemic Agents","cancer","de novo lipogenesis","eukaryotic initiation factor 3","lifespan","mRNA translation","metformin","phenformin","protein synthesis","reductive stress"],"relevance_confidence":97,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: metformin.","quality_checked_at":"2026-09-16T06:17:22.341306+00:00","duplicate_cluster_key":"id:10 1016 j molcel 2026 05 011","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Abstract contains controlled term: metformin.","Source terminology contains: metformin.","Abstract supplies longevity context: lifespan."],"matched_fields":["abstract","controlled terminology","abstract context"],"relevance_score":97,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5593","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}