{"type":"research","record":{"id":5625,"source_id":"pubmed","external_id":"42315078","title":"Semaglutide exerts anti-pulmonary fibrosis effects by inhibiting cellular senescence through activation of the Sirt1/HSF1/HSPs pathway.","authors":"Zeng Qian, Li Shuang, Luo Yu-Yang, Liao Min-Lin, Huang Chong-Mei, Liu Min-Hui, Liu Wei, Tang Si-Yuan","journal":"Biochemical pharmacology","published_on":"2026-06-18","doi":"10.1016/j.bcp.2026.118172","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42315078/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Biochemical pharmacology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:23.625+00:00","first_seen_at":"2026-09-16T01:17:10.167905+00:00","last_seen_at":"2026-09-16T06:17:23.625+00:00","status":"published","metadata":{"pmid":"42315078","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Semaglutide","Cellular Senescence","Sirtuin 1","Mice","Heat Shock Transcription Factors","Glucagon-Like Peptides","Male","Mice, Inbred C57BL","Pulmonary Fibrosis","Heat-Shock Proteins","Signal Transduction"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Idiopathic pulmonary fibrosis is an interstitial lung disease of unknown etiology with no effective treatment. Semaglut…","controlled_terms":["Animals","Semaglutide","Cellular Senescence","Sirtuin 1","Mice","Heat Shock Transcription Factors","Glucagon-Like Peptides","Male","Mice, Inbred C57BL","Pulmonary Fibrosis","Heat-Shock Proteins","Signal Transduction","Cellular senescence","Pulmonary fibrosis","Sirt1/HSF1/HSPs pathway"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: semaglutide.","quality_checked_at":"2026-09-16T06:17:23.755824+00:00","duplicate_cluster_key":"id:10 1016 j bcp 2026 118172","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"glp-1-therapies","is_published":true,"match_reasons":["Title contains controlled term: semaglutide.","Source terminology contains: semaglutide.","Title supplies longevity context: senescence."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"GLP-1 therapies","slug":"glp-1-therapies"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5625","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}