{"type":"research","record":{"id":5644,"source_id":"pubmed","external_id":"42335894","title":"Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.","authors":"Maura Fanti, Sebastian Brandhorst, Gerardo Navarrete, Arnold Diaz, Giacomo Giuliani, Dolly Chowdhury, Gabriel C Antunes, Todd E Morgan, Louis Dubeau, Valentina Villani, Laura Perin, Vasanti S Malik, Frank B Hu, Valter D Longo","journal":"Cell metabolism","published_on":"2026-06-23","doi":"10.1016/j.cmet.2026.05.015","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42335894/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Cell metabolism, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:23.625+00:00","first_seen_at":"2026-09-16T01:17:10.167905+00:00","last_seen_at":"2026-09-16T06:17:23.625+00:00","status":"published","metadata":{"pmid":"42335894","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Fibroblast Growth Factors","Longevity","Methionine","Male","Female","Humans","Glucagon-Like Peptide 1","Growth Hormone","Mice","Frailty","Dietary Supplements","Mice, Inbred C57BL","Diet","Insulin Resistance"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Southern European countries have some of the highest life expectancies in the world, yet they display relatively high f…","controlled_terms":["Animals","Fibroblast Growth Factors","Longevity","Methionine","Male","Female","Humans","Glucagon-Like Peptide 1","Growth Hormone","Mice","Frailty","Dietary Supplements","Mice, Inbred C57BL","Diet","Insulin Resistance","FGF21","GH","GLP-1","IGF-1","dietary intervention","insulin sensitivity","longevity","methionine","obesity","weight loss"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: glp-1.","quality_checked_at":"2026-09-16T06:17:23.755824+00:00","duplicate_cluster_key":"id:10 1016 j cmet 2026 05 015","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"glp-1-therapies","is_published":true,"match_reasons":["Title contains controlled term: glp-1.","Source terminology contains: glp-1.","Title supplies longevity context: longevity, healthspan."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"GLP-1 therapies","slug":"glp-1-therapies"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5644","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}