{"type":"research","record":{"id":5705,"source_id":"pubmed","external_id":"42730911","title":"Impact of caloric restriction on biological aging: insights from a composite biomarker index in older adults.","authors":"Cassidy A Guida, Fang-Chi Hsu, Rebecca Neiberg, Charles Semelka, Haiying Chen, Philip Kramer, Denise K Houston, Barbara Nicklas, Stephen B Kritchevsky, Michael E Miller","journal":"GeroScience","published_on":"2026-09-12","doi":"10.1007/s11357-026-02529-9","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42730911/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by GeroScience, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:26.92+00:00","first_seen_at":"2026-09-16T01:17:12.839665+00:00","last_seen_at":"2026-09-16T06:17:26.92+00:00","status":"published","metadata":{"pmid":"42730911","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Caloric restriction (CR) extends lifespan and delays age-related diseases in model organisms, yet its effects on biolog…","controlled_terms":["Aging","Biomarkers","Caloric restriction","Older adults"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: caloric restriction.","quality_checked_at":"2026-09-16T06:17:27.020352+00:00","duplicate_cluster_key":"id:10 1007 s11357-026-02529-9","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Title contains controlled term: caloric restriction.","Abstract contains controlled term: caloric restriction.","Source terminology contains: caloric restriction.","Title supplies longevity context: aging, older adult."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5705","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}