{"type":"research","record":{"id":5729,"source_id":"pubmed","external_id":"42653234","title":"Duration of Caloric Restriction Modulates Brain Redox Adaptation and Frailty During Aging.","authors":"Desanka Milanovic, Sladjan Pavlović, Milica Prvulovic, Slavica Borković Mitić, Srdjan Sokanovic, Smilja Pracer, Aleksandra Mladenovic","journal":"International journal of molecular sciences","published_on":"2026-08-13","doi":"10.3390/ijms27167229","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42653234/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by International journal of molecular sciences, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:26.92+00:00","first_seen_at":"2026-09-16T01:17:12.839665+00:00","last_seen_at":"2026-09-16T06:17:26.92+00:00","status":"published","metadata":{"pmid":"42653234","source":"NCBI PubMed E-utilities","mesh_terms":["Animals","Caloric Restriction","Aging","Brain","Oxidation-Reduction","Male","Rats, Wistar","Oxidative Stress","Rats","Antioxidants","Adaptation, Physiological","Glutathione","Frailty"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Caloric restriction (CR) is among the most effective nutritional interventions for promoting healthy aging, yet the inf…","controlled_terms":["Animals","Caloric Restriction","Aging","Brain","Oxidation-Reduction","Male","Rats, Wistar","Oxidative Stress","Rats","Antioxidants","Adaptation, Physiological","Glutathione","Frailty","aging","antioxidant enzymes","brain","caloric restriction","frailty index","oxidative stress","rat"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: caloric restriction.","quality_checked_at":"2026-09-16T06:17:27.020352+00:00","duplicate_cluster_key":"id:10 3390 ijms27167229","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Title contains controlled term: caloric restriction.","Abstract contains controlled term: caloric restriction.","Source terminology contains: caloric restriction.","Title supplies longevity context: aging, frailty."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5729","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}