{"type":"research","record":{"id":5736,"source_id":"pubmed","external_id":"42589577","title":"Sirtuins as Molecular Mediators of Caloric Restriction in the Pancreas: Implications for β-Cell Function, Metabolism, and Longevity.","authors":"Katarzyna Zgutka, Wioletta Mikołajek-Bedner, Kamila Szumilas, Maciej Tarnowski","journal":"International journal of molecular sciences","published_on":"2026-08-01","doi":"10.3390/ijms27156922","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42589577/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by International journal of molecular sciences, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:26.92+00:00","first_seen_at":"2026-09-16T01:17:12.839665+00:00","last_seen_at":"2026-09-16T06:17:26.92+00:00","status":"published","metadata":{"pmid":"42589577","source":"NCBI PubMed E-utilities","mesh_terms":["Sirtuins","Animals","Caloric Restriction","Humans","Insulin-Secreting Cells","Longevity","Pancreas","Energy Metabolism","Homeostasis"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Caloric restriction (CR), defined as a 30-60% decrease in ad libitum food intake without malnutrition, has emerged as o…","controlled_terms":["Sirtuins","Animals","Caloric Restriction","Humans","Insulin-Secreting Cells","Longevity","Pancreas","Energy Metabolism","Homeostasis","aging","caloric restriction","insulin secretion","metabolic homeostasis","pancreatic β-cells","sirtuins"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: caloric restriction.","quality_checked_at":"2026-09-16T06:17:27.020352+00:00","duplicate_cluster_key":"id:10 3390 ijms27156922","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Title contains controlled term: caloric restriction.","Abstract contains controlled term: caloric restriction.","Source terminology contains: caloric restriction.","Title supplies longevity context: longevity."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5736","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}