{"type":"research","record":{"id":5773,"source_id":"pubmed","external_id":"42442566","title":"Sleep-related Alzheimer's disease vulnerability in aging: A muscle-metabolic perspective.","authors":"Roberto Coccurello","journal":"Neuroscience and biobehavioral reviews","published_on":"2026-07-13","doi":"10.1016/j.neubiorev.2026.106869","publication_type":"Journal Article; Review","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42442566/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Neuroscience and biobehavioral reviews, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:29.08+00:00","first_seen_at":"2026-09-16T01:17:15.049137+00:00","last_seen_at":"2026-09-16T06:17:29.08+00:00","status":"published","metadata":{"pmid":"42442566","source":"NCBI PubMed E-utilities","mesh_terms":["Humans","Alzheimer Disease","Aging","Sleep Wake Disorders","Animals","Brain-Derived Neurotrophic Factor","Brain","Insulin Resistance","Fibronectins","Muscle, Skeletal","Sarcopenia","Sleep"]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Sleep disruption is a hallmark of aging and a plausible driver of Alzheimer's disease vulnerability. Reduced slow-wave…","controlled_terms":["Humans","Alzheimer Disease","Aging","Sleep Wake Disorders","Animals","Brain-Derived Neurotrophic Factor","Brain","Insulin Resistance","Fibronectins","Muscle, Skeletal","Sarcopenia","Sleep","Alzheimer’s disease","BDNF","Glymphatic clearance","Insulin resistance","Irisin/FNDC5","Neuroinflammation","Sleep fragmentation","Slow-wave sleep"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: sleep.","quality_checked_at":"2026-09-16T06:17:29.196395+00:00","duplicate_cluster_key":"id:10 1016 j neubiorev 2026 106869","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: sleep.","Abstract contains controlled term: sleep.","Source terminology contains: sleep.","Title supplies longevity context: aging."],"matched_fields":["title","abstract","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5773","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}