{"type":"research","record":{"id":5856,"source_id":"pubmed","external_id":"42489967","title":"Interstitial fluid rejuvenation through young-donor plasma exchange in cognitively impaired patients: a pilot safety and feasibility study.","authors":"Arne Søraas, Andreas Engvig, Dag Alnæs, Lana Nagmadin Karim, Elena Danilova, Mette Stausland Istre, Sara Nygaard, Tone Reinton Utgård, Sandra Ceprnjic, Olaug Reiakvam, Elisabeth Edvardsen, Lars T Westlye, Anders B Nygaard, John Arne Dahl, Lise Sofie Haug Nissen-Meyer, Håkon Ihle-Hansen, Petter Holland","journal":"GeroScience","published_on":"2026-07-23","doi":"10.1007/s11357-026-02435-0","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42489967/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by GeroScience, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:31.475+00:00","first_seen_at":"2026-09-16T01:17:17.735266+00:00","last_seen_at":"2026-09-16T06:17:31.475+00:00","status":"published","metadata":{"pmid":"42489967","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":"2026-09-16T06:17:16.341+00:00","abstract_text":"Heterochronic parabiosis improves physiological and cognitive function in aging rodents; these benefits appear to be de…","controlled_terms":["Alzheimer’s disease","Heterochronic blood exchange","Mild cognitive impairment","Therapeutic plasma exchange","Young donor plasma"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: plasma exchange.","quality_checked_at":"2026-09-16T06:17:31.546114+00:00","duplicate_cluster_key":"id:10 1007 s11357-026-02435-0","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"plasma-exchange","is_published":true,"match_reasons":["Title contains controlled term: plasma exchange.","Source terminology contains: plasma exchange.","Title supplies longevity context: rejuvenation."],"matched_fields":["title","controlled terminology","title context"],"relevance_score":100,"intelligence_topics":{"name":"Plasma exchange","slug":"plasma-exchange"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/5856","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}