{"type":"research","record":{"id":6565,"source_id":"pubmed","external_id":"42743924","title":"Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma.","authors":"Zan Gao, Le Sun, Jianlong Li, Heng Lv, Yingnan You, Kun Wang, Nan Su, Lin Wang, Nan Liu, Junhao Hu, Hong Jiang, Bing Shan, Yaoyang Zhang","journal":"Cell chemical biology","published_on":"2026-09-15","doi":"10.1016/j.chembiol.2026.08.012","publication_type":"Journal Article","evidence_level":"research-record","source_url":"https://pubmed.ncbi.nlm.nih.gov/42743924/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Research record published by Cell chemical biology, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:17.89+00:00","first_seen_at":"2026-09-16T06:17:17.934191+00:00","last_seen_at":"2026-09-16T06:17:17.89+00:00","status":"published","metadata":{"pmid":"42743924","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":null,"abstract_text":"Identifying therapeutic protein targets is challenging due to unpredictable druggability. Exploring multi-purpose drug…","controlled_terms":["HDAC inhibitors","RBBP7","chemical proteomics","drug target","rapamycin"],"relevance_confidence":100,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: rapamycin.","quality_checked_at":"2026-09-16T06:17:18.003619+00:00","duplicate_cluster_key":"id:10 1016 j chembiol 2026 08 012","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Title contains controlled term: rapamycin.","Source terminology contains: rapamycin."],"matched_fields":["title","controlled terminology"],"relevance_score":100,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/6565","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}