{"type":"research","record":{"id":6657,"source_id":"pubmed","external_id":"42577639","title":"Crocin I delays cellular senescence potentially via modulating SIRT1/PKM2 expression to improve lactate homeostasis in vitro .","authors":"Yicheng Fu, Zhiwei Ding, Yunchuang Chang, Chunxia Wu, Sanying Wang, Genxiang Mao, Huili Su","journal":"Experimental and therapeutic medicine","published_on":"2026-07-29","doi":"10.3892/etm.2026.13252","publication_type":"Journal Article","evidence_level":"preclinical","source_url":"https://pubmed.ncbi.nlm.nih.gov/42577639/","is_open_access":null,"cited_by_count":null,"editorial_summary":"Preclinical research published by Experimental and therapeutic medicine, indexed because it matched monitored longevity research terms. Inclusion in this index does not establish that an intervention is effective or safe.","source_updated_at":"2026-09-16T06:17:19.163+00:00","first_seen_at":"2026-09-16T06:17:19.199137+00:00","last_seen_at":"2026-09-16T06:17:19.163+00:00","status":"published","metadata":{"pmid":"42577639","source":"NCBI PubMed E-utilities","mesh_terms":[]},"integrity_checked_at":null,"abstract_text":"Crocin I has a protective effect against D-galactose-induced aging in rat models; however, its specific mechanism on de…","controlled_terms":["PKM2","SIRT1","cell senescence","crocin Ⅰ","glycolysis"],"relevance_confidence":75,"source_quality_score":95,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: cellular senescence.","quality_checked_at":"2026-09-16T06:17:19.270328+00:00","duplicate_cluster_key":"id:10 3892 etm 2026 13252","duplicate_of_id":null,"research_item_topics":[{"topic_slug":"senolytics","is_published":true,"match_reasons":["Title contains controlled term: cellular senescence.","Title supplies longevity context: senescence."],"matched_fields":["title","title context"],"relevance_score":75,"intelligence_topics":{"name":"Senolytics","slug":"senolytics"}}],"content_sources":{"name":"PubMed","homepage_url":"https://pubmed.ncbi.nlm.nih.gov/"}},"canonical_url":"https://www.immortal.life/research/6657","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}