{"type":"trials","record":{"id":100,"source_id":"clinicaltrials-gov","external_id":"NCT06975111","title":"Focusing on the Menopausal Transition to Improve Mid-Life Women's Health","brief_summary":"What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce menopause-related inflammation, restore a healthier cardiometabolic profile, reverse epigenetic aging, and reduce bothersome menopausal symptoms? The ultimate goal of this work is to attenuate future disease and enhance women's quality of life, extend healthspan and increase productivity.","overall_status":"Recruiting","phases":["PHASE2","PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"University of Colorado, Denver","enrollment":200,"countries":["United States"],"start_date":"2026-03-01","completion_date":"2030-10-01","last_update_date":"2026-07-21","source_url":"https://clinicaltrials.gov/study/NCT06975111","editorial_summary":"A registered PHASE2, PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.13201+00:00","last_seen_at":"2026-09-16T06:17:38.682+00:00","metadata":{"acronym":null,"organization":"University of Colorado, Denver","source_has_results":false},"controlled_terms":["Menopause","Menopause Hot Flashes","Menopause Related Conditions","Cardiovascular","Metformin","semaglutide","Anti-hypertensives","Lipid Lowering Medication","Life style intervention","Fezolinetant","Hormonal therapy"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: metformin.","quality_checked_at":"2026-09-16T06:17:38.84842+00:00","duplicate_cluster_key":"id:nct06975111","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Source terminology contains: metformin.","Abstract supplies longevity context: aging, healthspan.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/100","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}