{"type":"trials","record":{"id":106,"source_id":"clinicaltrials-gov","external_id":"NCT05093959","title":"Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction","brief_summary":"Met-PEF will be a randomized, double-blind, placebo-controlled trial to examine the effects of 20 weeks of 1500 mg/day of metformin on physical function, quality of life (QOL), microbiome diversity, leaky gut, and systemic inflammation in patients with 86 older patients with heart failure with preserved ejection fraction (HFpEF).","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Wake Forest University Health Sciences","enrollment":86,"countries":["United States"],"start_date":"2022-01-04","completion_date":"2026-04-16","last_update_date":"2026-06-10","source_url":"https://clinicaltrials.gov/study/NCT05093959","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.13201+00:00","last_seen_at":"2026-09-15T00:18:32.954+00:00","metadata":{"acronym":"Met-PEF","organization":"Wake Forest University Health Sciences","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05093959","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/106","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}