{"type":"trials","record":{"id":1092,"source_id":"clinicaltrials-gov","external_id":"NCT07817836","title":"Urban Exposome and Biological Age","brief_summary":"The goal of this observational study is to evaluate the impact of the urban exposome, including air pollution and lifestyle-related stressors, on biological aging, inflammatory pathways, oxidative stress, and DNA methylation patterns in healthy workers exposed to urban air pollution in the city of Pavia, Italy. The study population included 151 adult workers, divided into two groups: outdoor workers (including police officers, taxi drivers, and dustmen) and an indoor control group composed of office workers from the University of Pavia and ICS Maugeri hospital with minimal outdoor exposure. The main questions it aims to answer are: * Does chronic exposure to urban air pollutants such as NO2, SO2, O3, benzene, volatile organic compounds, and PM2.5 influence inflammatory cytokines, oxidative stress markers, and biological aging? * Is exposure to urban pollution associated with changes in DNA methylation patterns and epigenetic age acceleration? * How do lifestyle factors, nutritional status, sleep quality, physical activity, smoking habits, and perceived quality of life interact with the urban exposome and biological outcomes? Researchers will compare outdoor workers with indoor workers to evaluate differences in environmental exposure, inflammatory biomarkers, oxidative stress, DNA methylation profiles, and estimated biological age. Participants will: * Undergo clinical assessments, with interviews regarding occupational history. * Undergo anthropometric and nutritional evaluations, including body composition analysis and blood chemistry tests; answer questionnaires about physical activity, smoking habits, sleep quality, and perceived quality of life; undergo interviews about dietary habits. * Wear passive personal air samplers for approximately 5 working days to measure exposure to urban air pollutants. * Provide blood samples for analysis of inflammatory cytokines, oxidative stress markers, thyroid-related biomarkers, and epigenetic modifications. * Undergo DNA methylation analyses using epigenetic techniques to estimate biological age and evaluate associations between pollutant exposure and epigenetic changes. * Receive feedback regarding their environmental exposure and general health and nutritional status. This interdisciplinary observational study adopts an exposome-based approach integrating environmental monitoring, occupational medicine, nutrition, and epigenetics to better understand the relationship between urban environmental exposure and human health.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Pavia","enrollment":151,"countries":["Italy"],"start_date":"2024-11-21","completion_date":"2025-11-17","last_update_date":"2026-09-14","source_url":"https://clinicaltrials.gov/study/NCT07817836","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T12:17:15.31705+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":"IDEA","age_range":"18 Years","comparator":null,"organization":"University of Pavia","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["DNA Methylation Profile Associated With Urban Air Pollution Exposure — Baseline","Biological Age Estimated using an Epigenetic Clock Analysis in Workers Exposed to Urban Air Pollution — Baseline"],"design_description":null,"source_has_results":false},"controlled_terms":["Healthy Adult Participants"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct07817836","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-11-21 to 2025-11-17","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.680Z","intervention":[],"participants":151,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["DNA Methylation Profile Associated With Urban Air Pollution Exposure — Baseline","Biological Age Estimated using an Epigenetic Clock Analysis in Workers Exposed to Urban Air Pollution — Baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Abstract contains controlled term: biological age.","Title supplies longevity context: biological age.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/1092","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}