{"type":"trials","record":{"id":117,"source_id":"clinicaltrials-gov","external_id":"NCT03107884","title":"Role of Metformin on Muscle Health of Older Adults","brief_summary":"Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.","overall_status":"Active Not Recruiting","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"University of Utah","enrollment":64,"countries":["United States"],"start_date":"2019-08-01","completion_date":"2026-11-01","last_update_date":"2025-12-05","source_url":"https://clinicaltrials.gov/study/NCT03107884","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.13201+00:00","last_seen_at":"2026-09-15T00:18:32.954+00:00","metadata":{"acronym":null,"organization":"University of Utah","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct03107884","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/117","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}