{"type":"trials","record":{"id":136,"source_id":"clinicaltrials-gov","external_id":"NCT03451006","title":"Effect of Metformin on Frailty in 12 Subjects","brief_summary":"This study will test whether chronic metformin administration will improve longevity of the cell, improves its machinery by reducing aging-related biochemical parameters and thereby improving physical performance, as measured by short physical performance battery test.","overall_status":"Terminated","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":7,"countries":["United States"],"start_date":"2018-05-24","completion_date":"2021-12-16","last_update_date":"2022-11-17","source_url":"https://clinicaltrials.gov/study/NCT03451006","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Terminated. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.13201+00:00","last_seen_at":"2026-09-15T00:18:32.954+00:00","metadata":{"acronym":null,"organization":"Mayo Clinic","source_has_results":true},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct03451006","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/136","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}