{"type":"trials","record":{"id":138,"source_id":"clinicaltrials-gov","external_id":"NCT01808690","title":"EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes","brief_summary":"Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart disease. Poor insulin action, otherwise known as insulin resistance (IR), is the main factor causing heart disease in type 2 diabetes (T2D), but the cause of increased heart disease in T1D is unclear. IR may contribute to heart disease in T1D as in T2D, as the investigators and others have found the presence of IR in T1D. Much less is known about IR in T1D, but a better understanding of its role in T1D is critical to understanding causes of heart disease in T1D. The investigators long-term goal is to understand the early causes of heart disease in diabetes so that we can prevent it. The investigators unique initial findings suggest that even reasonably well-control…","overall_status":"Completed","phases":["PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"University of Colorado, Denver","enrollment":52,"countries":["United States"],"start_date":"2013-03-01","completion_date":"2016-12-02","last_update_date":"2021-09-30","source_url":"https://clinicaltrials.gov/study/NCT01808690","editorial_summary":"A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.13201+00:00","last_seen_at":"2026-09-15T00:18:32.954+00:00","metadata":{"acronym":"EMERALD","organization":"University of Colorado, Denver","source_has_results":true},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct01808690","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"metformin","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Metformin","slug":"metformin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/138","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}