{"type":"trials","record":{"id":147,"source_id":"clinicaltrials-gov","external_id":"NCT07485062","title":"Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes","brief_summary":"Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and physical function in this population. The MOTIVATE study is a randomized clinical trial designed to examine the effects of supervised exercise and diabetes treatment with semaglutide, alone or in combination, on cognitive function, physical health, and brain-related outcomes in older adults with Type 2 diabetes. Participants will be assigned to one of four study groups involving exercise training, control exercise, semaglutide treatment, or standard diabetes care. Participants will complete supervised exercise sessions three times per week for 32 weeks, with some participants also receiving weekly semaglutide injections for 16 weeks. Assessments will include cogniti…","overall_status":"Not Yet Recruiting","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"Western University, Canada","enrollment":164,"countries":["Canada"],"start_date":"2026-09-01","completion_date":"2029-05-01","last_update_date":"2026-08-20","source_url":"https://clinicaltrials.gov/study/NCT07485062","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.719473+00:00","last_seen_at":"2026-09-15T00:18:33.541+00:00","metadata":{"acronym":"MOTIVATE","organization":"Western University, Canada","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct07485062","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"glp-1-therapies","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"GLP-1 therapies","slug":"glp-1-therapies"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/147","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}