{"type":"trials","record":{"id":174,"source_id":"clinicaltrials-gov","external_id":"NCT06203392","title":"Effects of a Very Low Carbohydrate Ketogenic Diet or Mediterranean Diet on Markers of Musculoskeletal Health in Older Adults","brief_summary":"Preclinical data indicate that very low carbohydrate ketogenic diets (KD) may prevent progression of age-related sarcopenia (skeletal muscle decline) but also may disturb bone metabolism. The investigators will pilot test a randomized trial comparing the effects of short-term adaptation to a well-formulated ketogenic diet and Mediterranean diet on markers of bone metabolism and muscle function in older adults. The expected results will help inform the benefit-risk assessment for older patients considering longer term use of KD therapy.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Florida","enrollment":12,"countries":["United States"],"start_date":"2024-07-15","completion_date":"2025-11-24","last_update_date":"2026-01-28","source_url":"https://clinicaltrials.gov/study/NCT06203392","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.719473+00:00","last_seen_at":"2026-09-25T06:25:45.678+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 80 Years","comparator":"Mediterranean diet for six weeks","organization":"University of Florida","interventions":["Very low carbohydrate ketogenic diet","Mediterranean diet"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Rate of enrollment — Monthly. Up to 24 months.","Screen failure rate (percentage) — Monthly. Up to 24 months.","Treatment-specific retention rates — Either after the endline visit or when participant is withdrawn or withdraws from…","Treatment-specific adherence rates — Either after the endline visit or when participant is withdrawn or withdraws from…"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","source_has_results":false},"controlled_terms":["Aging","Musculoskeletal Diseases","Very low carbohydrate ketogenic diet","Mediterranean diet"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: ketogenic diet.","quality_checked_at":"2026-09-25T06:25:48.368501+00:00","duplicate_cluster_key":"id:nct06203392","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-07-15 to 2025-11-24","comparator":"Mediterranean diet for six weeks","confidence":"structured-source","population":"ALL · 55 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:45.700Z","intervention":["Very low carbohydrate ketogenic diet","Mediterranean diet"],"participants":12,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Rate of enrollment — Monthly. Up to 24 months.","Screen failure rate (percentage) — Monthly. Up to 24 months.","Treatment-specific retention rates — Either after the endline visit or when participant is withdrawn or withdraws from…","Treatment-specific adherence rates — Either after the endline visit or when participant is withdrawn or withdraws from…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"ketogenic-diets","is_published":true,"match_reasons":["Title contains controlled term: ketogenic diet.","Abstract contains controlled term: ketogenic diet.","Source terminology contains: ketogenic diet.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Ketogenic diets","slug":"ketogenic-diets"}},{"topic_slug":"mediterranean-diet","is_published":true,"match_reasons":["Title contains controlled term: mediterranean diet.","Abstract contains controlled term: mediterranean diet.","Source terminology contains: mediterranean diet.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Mediterranean diet","slug":"mediterranean-diet"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/174","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}