{"type":"trials","record":{"id":175,"source_id":"clinicaltrials-gov","external_id":"NCT07203196","title":"Circadian Health Regulation and Optimization for Rejuvenation Outcomes","brief_summary":"In this single arm intervention trial, the investigators will assess the impact of a personalized lifestyle plan, centered on supporting biological rhythms, on blood sugar levels, physical, cognitive and immune function in older adults with a habitual eating window of 12 hours or more, and elevated blood glucose levels. All participants will be provided with a personalized circadian rhythm optimization plan (CRO) centered on improving (1) diet, (2) exercise (3) sleep habits based on their body's natural rhythms. The study includes a 2-week screening/baseline assessments, with follow-up health assessments at 2-months.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Salk Institute for Biological Studies","enrollment":16,"countries":["United States"],"start_date":"2025-10-22","completion_date":"2026-04-01","last_update_date":"2025-12-31","source_url":"https://clinicaltrials.gov/study/NCT07203196","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.719473+00:00","last_seen_at":"2026-09-25T07:05:20.248+00:00","metadata":{"sex":"ALL","acronym":"CHRONO","age_range":"50 Years to 80 Years","comparator":null,"organization":"Salk Institute for Biological Studies","interventions":["Circadian Rhythm Optimization"],"registry_source":"ClinicalTrials.gov","outcome_measures":["HbA1c (%) — Baseline and 90 days","Grip Strength — Baseline and 90 days","Isometric Knee Strength — Baseline and 90 days","VO2 Max — Baseline and 90 days","Time to 85% of Age Predicted Maximal Heart Rate — Baseline and 90 days","Flanker Inhibitory and Control and Attention Test (Fully-Corrected T-score) — Baseline and 90 days","Dimensional Change Card Sort (Fully-Corrected T-score) — Baseline and 90 days","Pattern Comparison Processing Speed Test (Fully-Corrected T-score) — Baseline and 90 days","Picture Sequence Memory test (Fully-Corrected T-score) — Baseline and 90 days","Trail Making Test — Baseline and 90 days","Glucagon (pg/mL) — Baseline and 90 days","Leptin (ng/mL) — Baseline and 90 days","IL-1α (pg/mL) — Baseline and 90 days","IL-1β (pg/mL) — Baseline and 90 days","IL-2 (pg/mL) — Baseline and 90 days","IL-3 (pg/mL) — Baseline and 90 days","IL-4 (pg/mL) — Baseline and 90 days","IL-5 (pg/mL) — Baseline and 90 days","IL-6 (pg/mL) — Baseline and 90 days","IL-7 (pg/mL) — Baseline and 90 days"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Aging, Healthy","Blood Sugar; High","Blood Sugar (Glucose) Control","Time Restricted Eating","Circadian Dysregulation","Circadian Rhythm Optimization"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: circadian.","quality_checked_at":"2026-09-25T07:05:30.295959+00:00","duplicate_cluster_key":"id:nct07203196","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-10-22 to 2026-04-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T07:05:20.289Z","intervention":["Circadian Rhythm Optimization"],"participants":16,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["HbA1c (%) — Baseline and 90 days","Grip Strength — Baseline and 90 days","Isometric Knee Strength — Baseline and 90 days","VO2 Max — Baseline and 90 days","Time to 85% of Age Predicted Maximal Heart Rate — Baseline and 90 days","Flanker Inhibitory and Control and Attention Test (Fully-Corrected T-score) — Baseline and 90 days","Dimensional Change Card Sort (Fully-Corrected T-score) — Baseline and 90 days","Pattern Comparison Processing Speed Test (Fully-Corrected T-score) — Baseline and 90 days","Picture Sequence Memory test (Fully-Corrected T-score) — Baseline and 90 days","Trail Making Test — Baseline and 90 days","Glucagon (pg/mL) — Baseline and 90 days","Leptin (ng/mL) — Baseline and 90 days","IL-1α (pg/mL) — Baseline and 90 days","IL-1β (pg/mL) — Baseline and 90 days","IL-2 (pg/mL) — Baseline and 90 days","IL-3 (pg/mL) — Baseline and 90 days","IL-4 (pg/mL) — Baseline and 90 days","IL-5 (pg/mL) — Baseline and 90 days","IL-6 (pg/mL) — Baseline and 90 days","IL-7 (pg/mL) — Baseline and 90 days"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"sleep","is_published":true,"match_reasons":["Title contains controlled term: circadian.","Abstract contains controlled term: sleep, circadian.","Source terminology contains: circadian.","Title supplies longevity context: rejuvenation.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Sleep","slug":"sleep"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/175","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}