{"type":"trials","record":{"id":183,"source_id":"clinicaltrials-gov","external_id":"NCT05769335","title":"Calories or Time Restriction to Alter Biomarkers of Aging and Diabetes","brief_summary":"Type 2 diabetes and cardiovascular disease are an increasing problem in Australia and around the world, and are partly linked to increased rates of obesity, together with sedentary lifestyles. This study will compare caloric restriction (CR) diets that restrict the amount of food that is eaten with CR diets that also restrict the time that the food is eaten, to either early or late in the day, on risk factors for type 2 diabetes and cardiovascular diseases over 2 months.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Adelaide","enrollment":114,"countries":["Australia"],"start_date":"2023-03-15","completion_date":"2025-04-17","last_update_date":"2025-05-09","source_url":"https://clinicaltrials.gov/study/NCT05769335","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.719473+00:00","last_seen_at":"2026-09-15T00:18:34.37+00:00","metadata":{"acronym":"OMIT","organization":"University of Adelaide","source_has_results":false},"controlled_terms":[],"relevance_confidence":68,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Published automatically with 68% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05769335","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"caloric-restriction","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["abstract"],"relevance_score":68,"intelligence_topics":{"name":"Caloric restriction","slug":"caloric-restriction"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/183","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}