{"type":"trials","record":{"id":185,"source_id":"clinicaltrials-gov","external_id":"NCT05302596","title":"Semaglutide Use in Elderly Obese Patients","brief_summary":"This is a single-center, prospective, controlled, randomized and open label study to investigate the effect of the semaglutide addition to standard of care weight loss intervention (personalized lifestyle and exercise) in elderly obese subjects on body weight and body composition as assessed by DEXA.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"State University of New York at Buffalo","enrollment":16,"countries":["United States"],"start_date":"2022-09-01","completion_date":"2024-10-30","last_update_date":"2025-04-17","source_url":"https://clinicaltrials.gov/study/NCT05302596","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:00.719473+00:00","last_seen_at":"2026-09-25T06:00:20.219+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"65 Years","comparator":"standard of care only","organization":"State University of New York at Buffalo","interventions":["Semaglutide Pen Injector"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Body Composition as Total Fat Mass/ Total Fat-free Mass Ratio — 16 weeks","Body Weight — 16 weeks","Total Fat Mass — 16 weeks","Total Fat-free Mass (Lean Mass) — 16 weeks"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":true},"controlled_terms":["Obesity","Aging","Semaglutide Pen Injector"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: semaglutide.","quality_checked_at":"2026-09-25T06:00:20.957351+00:00","duplicate_cluster_key":"id:nct05302596","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-09-01 to 2024-10-30","comparator":"standard of care only","confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:20.228Z","intervention":["Semaglutide Pen Injector"],"participants":16,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Body Composition as Total Fat Mass/ Total Fat-free Mass Ratio — 16 weeks","Body Weight — 16 weeks","Total Fat Mass — 16 weeks","Total Fat-free Mass (Lean Mass) — 16 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"glp-1-therapies","is_published":true,"match_reasons":["Title contains controlled term: semaglutide.","Abstract contains controlled term: semaglutide.","Source terminology contains: semaglutide.","Title supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"GLP-1 therapies","slug":"glp-1-therapies"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/185","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}