{"type":"trials","record":{"id":20019,"source_id":"clinicaltrials-gov","external_id":"NCT07242833","title":"Evaluation of the Effect of Seasonality on Biological Age in Adults","brief_summary":"This research aims to provide insights on how seasonal variations influence biological age and enhance the design and analysis of long-term lifestyle interventions targeting biological clocks. Aging is a gradual decline in cellular and organ functions, significantly increasing the risk of non-communicable and infectious diseases. Recent research has focused on identifying aging biomarkers that can better predict functional capability in healthy individuals. Biological age clocks, which can be measured from samples like blood or saliva, are emerging as valuable tools for assessing the pace of aging and calculating age acceleration-the difference between chronological and biological age. These clocks utilize molecular and clinical data, including DNA methylation and plasma proteomics, to predict future health outcomes, such as disease risk and mortality. Various DNA methylation-based clocks have been developed, with the Dunedin Pace of Aging (PoAm) offering a more precise modeling of physiological changes over time. Lifestyle factors, including diet and physical activity, can influence age acceleration, suggesting that lifestyle interventions may impact biological aging. Current evidence indicates that three specific epigenetic clocks-PhenoAge, GrimAge, and Dunedin PACE-are particularly effective in detecting beneficial effects on aging trajectories. However, the stability of these clocks during long-term lifestyle interventions remains unclear, as they can exhibit variability over short periods and may be affected by factors influenced by seasonal changes, such as Vitamin D levels, climate, and white blood cells composition. To investigate these seasonal effects on biological age, a proposed observational study will track changes over a 12-month period in middle-aged and older adults.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Société des Produits Nestlé (SPN)","enrollment":60,"countries":["Switzerland"],"start_date":"2025-11-24","completion_date":"2027-08-01","last_update_date":"2026-09-23","source_url":"https://clinicaltrials.gov/study/NCT07242833","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-23T12:17:13.490236+00:00","last_seen_at":"2026-09-25T06:25:39.067+00:00","metadata":{"sex":"ALL","acronym":"SeasonAGE","age_range":"40 Years","comparator":null,"organization":"Société des Produits Nestlé (SPN)","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Effect of seasonality (meaning change between summer and winter observed in western Europe) on biological age calculate…","Underlying factors explaining the seasonal differences in biological age measurements across various epigenetic clocks…","Differences and associations in biological age measurements between various epigenetic clocks. — From enrollment, 4 tim…","Relationship between biological age and individuals' self-assessment of their overall health. — From enrollment, 4 time…"],"design_description":null,"source_has_results":false},"controlled_terms":["Aging","Aging, Biological","Aging, Healthy","BIOLOGICAL CLOCKS","Biological Clock Disturbance"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: biological age.","quality_checked_at":"2026-09-25T06:25:42.287439+00:00","duplicate_cluster_key":"id:nct07242833","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-11-24 to 2027-08-01","comparator":null,"confidence":"structured-source","population":"ALL · 40 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:39.070Z","intervention":[],"participants":60,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Effect of seasonality (meaning change between summer and winter observed in western Europe) on biological age calculate…","Underlying factors explaining the seasonal differences in biological age measurements across various epigenetic clocks…","Differences and associations in biological age measurements between various epigenetic clocks. — From enrollment, 4 tim…","Relationship between biological age and individuals' self-assessment of their overall health. — From enrollment, 4 time…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"biological-age-biomarkers","is_published":true,"match_reasons":["Title contains controlled term: biological age.","Abstract contains controlled term: biological age, aging biomarker.","Title supplies longevity context: biological age.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Biological age biomarkers","slug":"biological-age-biomarkers"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/20019","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}