{"type":"trials","record":{"id":21597,"source_id":"clinicaltrials-gov","external_id":"NCT07081282","title":"Precision Stratification for Frailty and Cognitive Decline","brief_summary":"The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks trial period to prevent frailty and promote social bonding.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National University of Singapore","enrollment":252,"countries":["Singapore"],"start_date":"2025-07-01","completion_date":"2027-05-31","last_update_date":"2025-07-23","source_url":"https://clinicaltrials.gov/study/NCT07081282","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:07.557436+00:00","last_seen_at":"2026-09-25T06:10:25.747+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 85 Years","comparator":"Active Control; Control","organization":"National University of Singapore","interventions":["Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB)","Centre-Based Exercise Health Session"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Frailty Status: - Edmonton Frailty Scale - Clinical Frailty Scale - Oral Frailty Index-8 — From enrollment to the end o…","Presence of Sarcopenia: - Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F) Questi…","Presence of Cognitive Decline: - Montreal Cognitive Assessment - Symbol Digit Modalities Test - Cognitive Predictive Ri…","Immunological Biomarkers: - C1q (complement component 1q) - IL-6 (Interleukin-6) — From enrollment to the end of treatm…","Skeletomuscular Biomarkers: - IGF-1 (Insulin-like Growth Factor-1) - Myostatin — From enrollment to the end of treatmen…","Self-Care Ability - Self-Care of Chronic Illness Inventory (SCCII) — From enrollment to the end of treatment at 12 week…","Physical Activity Level - Global Physical Activity Questionnaire (GPAQ) — From enrollment to the end of treatment at 12…","Physical Function - Short Physical Performance Battery (SPPB) — From enrollment to the end of treatment at 12 weeks.","Intrinsic Capacity - World Health Organization (WHO) Integrated Care for Older People (ICOPE) tool — From enrollment to…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Frailty","Cognitive Decline","Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB)","Centre-Based Exercise Health Session"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: frailty.","quality_checked_at":"2026-09-25T06:10:37.875473+00:00","duplicate_cluster_key":"id:nct07081282","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-07-01 to 2027-05-31","comparator":"Active Control; Control","confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:10:25.818Z","intervention":["Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB)","Centre-Based Exercise Health Session"],"participants":252,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Frailty Status: - Edmonton Frailty Scale - Clinical Frailty Scale - Oral Frailty Index-8 — From enrollment to the end o…","Presence of Sarcopenia: - Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F) Questi…","Presence of Cognitive Decline: - Montreal Cognitive Assessment - Symbol Digit Modalities Test - Cognitive Predictive Ri…","Immunological Biomarkers: - C1q (complement component 1q) - IL-6 (Interleukin-6) — From enrollment to the end of treatm…","Skeletomuscular Biomarkers: - IGF-1 (Insulin-like Growth Factor-1) - Myostatin — From enrollment to the end of treatmen…","Self-Care Ability - Self-Care of Chronic Illness Inventory (SCCII) — From enrollment to the end of treatment at 12 week…","Physical Activity Level - Global Physical Activity Questionnaire (GPAQ) — From enrollment to the end of treatment at 12…","Physical Function - Short Physical Performance Battery (SPPB) — From enrollment to the end of treatment at 12 weeks.","Intrinsic Capacity - World Health Organization (WHO) Integrated Care for Older People (ICOPE) tool — From enrollment to…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"frailty","is_published":true,"match_reasons":["Title contains controlled term: frailty.","Abstract contains controlled term: frailty.","Source terminology contains: frailty.","Title supplies longevity context: frailty, frail.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Frailty","slug":"frailty"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21597","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}