{"type":"trials","record":{"id":21603,"source_id":"clinicaltrials-gov","external_id":"NCT05857241","title":"Therapeutic Fasting and Immune Aging","brief_summary":"Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","enrollment":20,"countries":["France"],"start_date":"2025-04-01","completion_date":"2026-03-01","last_update_date":"2025-04-08","source_url":"https://clinicaltrials.gov/study/NCT05857241","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:07.557436+00:00","last_seen_at":"2026-09-25T06:15:06.064+00:00","metadata":{"sex":"ALL","acronym":"JÛVENILE","age_range":"65 Years","comparator":null,"organization":"Centre Hospitalier Universitaire de Saint Etienne","interventions":["Fasting mimicking diet (FMD)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["rate of premature discontinuation of the fasting-mimicking diet — between Day 14 and Day 21","serious and non-serious adverse events reported — Between day 0 to day 42","composite outcome: evolution of biological biochemic parameters — Day 0 to Day 42","composite outcome: evolution of biological blood parameters — Day 0 to Day 42","composite outcome: evolution biological inflammatory parameters — Day 0 to Day 42"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Fasting","Diet, Healthy","Fasting mimicking diet (FMD)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: immune aging.","quality_checked_at":"2026-09-25T06:15:09.632521+00:00","duplicate_cluster_key":"id:nct05857241","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-04-01 to 2026-03-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:15:06.084Z","intervention":["Fasting mimicking diet (FMD)"],"participants":20,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["rate of premature discontinuation of the fasting-mimicking diet — between Day 14 and Day 21","serious and non-serious adverse events reported — Between day 0 to day 42","composite outcome: evolution of biological biochemic parameters — Day 0 to Day 42","composite outcome: evolution of biological blood parameters — Day 0 to Day 42","composite outcome: evolution biological inflammatory parameters — Day 0 to Day 42"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"immune-aging","is_published":true,"match_reasons":["Title contains controlled term: immune aging.","Abstract contains controlled term: immunosenescence.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Immune ageing","slug":"immune-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21603","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}