{"type":"trials","record":{"id":21619,"source_id":"clinicaltrials-gov","external_id":"NCT03175874","title":"Autophagy and Pathological Aging","brief_summary":"Autophagy is recognized as a central mechanism for the regulation of aging. . Osteoporosis (OA) and Alzheimer's disease (AD) are two forms of pathological aging, sometimes entangled, including an over-risk of OP in AD and degradation of cognitive functions after OP fracture, but the link between These two pathologies remain poorly understood. The aim of this prospective pilot study is to evaluate the level of autophagy of osteocytes (OST) in postmenopausal women with OP and to explore the hypothesis that the defect of autophagy is one of the physiopathological links of the OP During the MA","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Centre Hospitalier Universitaire de Nice","enrollment":82,"countries":["France"],"start_date":"2017-12-20","completion_date":"2021-05-20","last_update_date":"2026-03-24","source_url":"https://clinicaltrials.gov/study/NCT03175874","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:08.26846+00:00","last_seen_at":"2026-09-25T06:20:19.667+00:00","metadata":{"sex":"FEMALE","acronym":"AVP","age_range":"65 Years","comparator":null,"organization":"Centre Hospitalier Universitaire de Nice","interventions":["Hip bone sampling"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Quantification of autophagy — at inclusion","Bone mineral density — at inclusion","25 OH vitamin D (ng/ml). — at inclusion"],"design_description":"NON RANDOMIZED · SINGLE GROUP · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Osteoporosis","Hip bone sampling"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: autophagy.","quality_checked_at":"2026-09-25T06:20:27.00315+00:00","duplicate_cluster_key":"id:nct03175874","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-12-20 to 2021-05-20","comparator":null,"confidence":"structured-source","population":"FEMALE · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:19.691Z","intervention":["Hip bone sampling"],"participants":82,"study_design":"NON RANDOMIZED · SINGLE GROUP · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Quantification of autophagy — at inclusion","Bone mineral density — at inclusion","25 OH vitamin D (ng/ml). — at inclusion"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"autophagy","is_published":true,"match_reasons":["Title contains controlled term: autophagy.","Abstract contains controlled term: autophagy.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Autophagy","slug":"autophagy"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21619","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}