{"type":"trials","record":{"id":21647,"source_id":"clinicaltrials-gov","external_id":"NCT03473288","title":"Rejuvenation of Aged Muscle Stem Cells Through Exercise","brief_summary":"The proposed study will establish a newly-identified signaling pathway regulating both autophagy and apoptosis in human satellite cells. These findings will allow for novel pharmacological targets in satellite cells to return regenerative capacity to elderly individuals. Up to 80 adults, 21 years of age and greater, will undergo a consent visit followed by three blood draws and muscle biopsy visits- baseline (pre), after the first exercise bout (post-acute), and after the 12 week training program (post-chronic). Blood will be obtained and tested for inflammatory (IL-6/TNF/IL-1) and endocrine markers (Testosterone/Estrogen/Thyroid hormone). As part of the intervention, participants will undergo moderate intensity treadmill exercise three times per week for 10-12 weeks or serve as sedentary controls. Muscle stem cell function will be compared across age groups at each time point using a One Way ANOVA or t test for specific comparisons. An alternative analysis will be a longitudinal design following muscle stem cell function from each individual before and after exercise training. This analysis will be performed with repeated measure ANOVAs. Data will be analyzed using GraphPad Prism 6 statistical software. Significance will be accepted as p\\<.05. Thigh Muscle biopsies may result in momentary pain and discomfort, burning or bleeding, numbness, and rarely fainting or infection. The incision site may leave a scar and muscle soreness may be present up to ten days after the biopsy. While the local numbing medicine xylocaine is almost entirely free from allergic properties (such as causing hives), an allergic reaction is possible, and the participant will not be given xylocaine if they have a history of such a reaction. The xylocaine will be given by a small injection into the skin at the site of the muscle biopsy. Risks associated with a standard blood draw include momentary discomfort and/or bruising. In addition, there is a minimal risk of infection, excess bleeding, clotting, and fainting. An exercise program may result in muscle, bone and/or joint soreness, discomfort and/or injury. All collected data will be stored in a locked file to be accessed only by Dr. White and his study staff. Study records that identify subjects will be kept confidential as required by law.","overall_status":"Withdrawn","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Duke University","enrollment":0,"countries":["United States"],"start_date":"2021-01-01","completion_date":"2021-06-06","last_update_date":"2021-06-10","source_url":"https://clinicaltrials.gov/study/NCT03473288","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Withdrawn. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-24T01:17:08.26846+00:00","last_seen_at":"2026-09-25T06:05:28.576+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"21 Years","comparator":"Moderate Intensity Treadmill Exercise; Sedentary Controls","organization":"Duke University","interventions":["Exercise","Sedentary"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Muscle Stem Cell Function by Age Group — Baseline, 1 Week Post Baseline, and 12 Weeks Post Baseline"],"design_description":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","source_has_results":false},"controlled_terms":["Autophagy and Apoptosis in Human Satellite Cells","Exercise","Sedentary"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: stem cell.","quality_checked_at":"2026-09-25T06:05:30.9321+00:00","duplicate_cluster_key":"id:nct03473288","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-01-01 to 2021-06-06","comparator":"Moderate Intensity Treadmill Exercise; Sedentary Controls","confidence":"structured-source","population":"ALL · 21 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:05:28.587Z","intervention":["Exercise","Sedentary"],"participants":0,"study_design":"RANDOMIZED · PARALLEL · BASIC SCIENCE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Muscle Stem Cell Function by Age Group — Baseline, 1 Week Post Baseline, and 12 Weeks Post Baseline"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"stem-cells","is_published":true,"match_reasons":["Title contains controlled term: stem cell.","Abstract contains controlled term: stem cell.","Title supplies longevity context: rejuvenation.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Stem cells","slug":"stem-cells"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/21647","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}